Spectrin alpha/beta-1 Antibodies

Target Information

Spectrin is a cytoskeletal protein crucial for maintaining the structural integrity and flexibility of cell membranes, especially in erythrocytes. Spectrin consists of alpha and beta subunits that form heterodimers, which further assemble into tetramers at the cell membrane. The alpha subunit genes include SPTA1 and SPTAN1, and the beta subunits are encoded by four conventional genes: SPTB, SPTBN1, SPTBN2, and SPTBN4. Spectrin's modular structure comprises spectrin repeats, integral to its function as a scaffold for various cellular components. It interacts with other proteins such as actin and ankyrin, stabilizing cells against mechanical stress. Spectrin is ubiquitous in different cell types and plays a role in signaling pathways, cellular morphology, and intracellular transport. Pathogenic variants in spectrin genes can lead to neurological disorders due to their role in the nervous system's organization. While primarily known for its function in erythrocytes, spectrin's role in cellular matrix organization positions it as a target for research in cell biology and disease mechanisms.

Synonyms

SPTA1/SPTB